OHLABS
Ubiquitin signaling
in development and disease
Mission
We seek to push the boundaries of biological research in an open, engaging, collaborative, and safe environment. We value diversity, equity, and inclusion, and we'll make sure that everyone can succeed in our lab. We seek to have an open mind about where our science leads us and pursue interesting problems. Our lab is a place of learning and self-discovery. We will provide you with whatever training you need to help further your future career goals. We prioritize our health and mental well-being. We expect our members to be self-motivated, excited about tackling challenging problems, and unafraid of asking questions. Most importantly, we want you to have fun!
We are always looking for talented scientists!
Postdoctoral Research Fellows
Our lab is actively recruiting post-doctoral research fellows interested in dissecting mechanisms of ubiquitin-dependent control. We are part of the Center for Cancer Research at Massachusetts General Hospital and the Department of Medicine at Harvard Medical School.
We study how the ubiquitin-proteasome system (UPS) masterminds key decision-making events, including cell cycle progression, gene expression control, and tissue type specification. We also strive to understand how dysfunction of the UPS contributes to various malignancies. Our group recently identified how the E3 ubiquitin ligase APC/C (anaphase promoting complex) controls the pluripotent identity of human embryonic stem cells by enabling the activation of stem cells genes upon exit from mitosis (Nature, PMID: 32076268). We are currently working towards understanding the prevalence of APC/C-dependent regulation in other tissue types, including those of tumorigenic origin, and characterizing the molecular basis of this mechanism. Some of our other ongoing projects include (i) deciphering the chromatin-bound ubiquitin code, (ii) elucidating a systems-level framework for the UPS, and (iii) developing small molecule inhibitors that co-opt the ubiquitin machinery (PROTACs) to target tumor substrates. To tackle these broad areas, we employ a multidisciplinary approach, combining global and quantitative analyses with hypothesis-driven, mechanistic studies.
We are seeking a self-motivated investigator who has a solid background in biochemistry and/or cell biology. The ideal candidate is a strong bench scientist who can think creatively and has a proven track of success in a laboratory setting (i.e. a first author publication). A PhD and/or MD is required for this position and the degree should be conferred within the last three years. The candidate will be expected to carry out an independent research project under the guidance of Dr. Oh and will hold joint academic appointments at the Center for Cancer Research, Massachusetts General Hospital and the Department of Medicine, Harvard Medical School. Additionally, our lab is part of an exceptionally collaborative department, and the candidate will have numerous opportunities to engage with both basic scientists and clinicians.
Interested candidates should submit a cover letter and a CV to Dr. Oh at eugene.oh@mgh.harvard.edu. Further information can be found at www.ohlabs.org.
Visting students
We welcome visiting students outside of the Harvard system who want to pursue a thesis project in our lab. We offer a rich and stimulating environment for those who want to carry out an independent research project. Interested students should directly contact Eugene Oh at eugene.oh@mgh.harvard.edu for more information.
Research Technicians
All of our research technicians are expected to carry out an independent project under the guidance of Dr. Oh or a senior member of the lab. No experience is required and training will be provided. You should hold a Bachelor's degree. Interested candidates should directly contact Eugene Oh at eugene.oh@mgh.harvard.edu for more information.